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KMID : 0363620080290020116
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Journal of Korean Oriental Medicine
2008 Volume.29 No. 2 p.116 ~ p.132
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The Inhibitory Effects of Bimanbang-1(肥滿1號方) on the Obese-mouse Fed High-fat Diet
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Sin Hong-Jung
Yoon Il-Ji
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Abstract
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Objective: This study investigated the effects of Bimanbang-1 ( 1 : here in after referred to BMB-1) on the obese gene and obese inhibitory.
Methods: C57BL/6 mice were induced by high fat diet. Mice were divided into three groups (normal, high fat diet
with control, high fat diet with BMB-1 extract) and fed for 15 weeks. Items of this experimental study are as follows: body weight change, final body weight, the weight change of the adipocytes in body, the level change of LFT, NEFA and creatinine, the expression of β3AR and leptin gene in primary adipocytes, the production change of leptin in primary adipocytes, the expression of β3AR, leptin and TNF-α in adipocytes tissue.
Result: 1. All experimental groups showedthat the weight change decreased considerably and the high density group showedthat the final weight decreased considerably. 2. The high density group showed that the amount of the adipocyte in weight decreased considerably. 3. All experimental groups showedthat the amount of ALT decreased considerably, and AST decreased in the high density group. However, the amount of creatinine and glucose did not increase considerably. 4. All experimental groups showed that the amount of total cholesterol, LDL-cholesterol, triglyceride, and NEFA decreased, and HDL-cholesterol increased considerably. 5. The high density groups showedthat the amount of leptin decreased considerably. 6. All experimental groups showed that the revelation of β3AR in primary adipose cell and 3T3-L1 cell increased considerably, and that the revelation of leptin and TNF-α in primary adipose cellsand 3T3-L1 cells decreased considerably. 7. All experimental groups showed that the size of adipocyte in adipocytes tissue decreased. 8. All experimental groups showed that the adipose vacuoles in liver tissue decreased considerably.
Conclusion: The findings suggest that Bimanbang-1 causes weight loss and histological change, thus it may be
effective to treat obesity.
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KEYWORD
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BMB-1 (Bimanbang-1), obese-mouse, obese gene, obese inhibitory, adipocyte, liver tissue
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